New study looks at ‘magic’ mushrooms as treatment for depression, without the psychedelic high

A new study by the Centre for Addiction and Mental Health (CAMH) will attempt to harness the antidepressant power of psilocybin mushrooms, but without the psychedelic experience.

Psilocybin is the hallucinogenic chemical compound in “magic” mushrooms that generates a psychedelic high. However, clinical trials have shown psilocybin mushrooms also have antidepressant effects on people whose depression is resistant to other treatments, when combined with intensive psychotherapy.

Over a period of three years, researchers at CAMH will try to learn whether the psychedelic experience itself is necessary to treat depression in a federally-funded study that lead researcher Dr. Ishrat Husain says is the first of its kind.

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